Key result
Prostacyclin, EDRF, and active oxygens modulate platelet-endothelial cell interactions in vitro.
Why the study?
The mechanisms and roles of prostacyclin, EDRF, and active oxygens in PMN-dependent platelet adhesion to endothelial cells induced by PAF were unclear.
In vitro findings suggest that prostacyclin, EDRF, and active oxygens are important modulators of leukocyte-dependent platelet adhesion to endothelial cells.
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In vitro data do not support PMN soluble factors in adhesion; leaves open direct cell-contact mechanisms for in vivo study.
Hirafuji et al. (1993) studied this question. Platelet-activating factor (PAF) and PMN sonicates was evaluated on Platelet adhesion to endothelial cells. In vitro experiments demonstrated that prostacyclin, EDRF, and active oxygens are important modulators of intercellular interactions between platelets and endothelial cells.
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