Key result
Thrombin and epinephrine/ADP stimulation of whole blood demonstrated that monocytes and neutrophils bind activated platelets through GMP-140, with monocytes showing a competitive advantage.
Population
Whole blood (in vitro model)
Comparison
Platelet agonists with or without inhibitors vs Different agonist and inhibitor conditions
Design
Preclinical
Authors
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Does not inform clinical practice; leaves open whether GMP-140 targeting alters thromboinflammation in vivo.
This study elucidates the dynamic interaction of blood cells, demonstrating that monocytes and neutrophils bind activated platelets via GMP-140, providing a mechanistic link between coagulative and inflammatory processes.
Rinder et al. (1991) studied this question. Platelet agonists (thrombin, epinephrine/ADP) was evaluated on Leukocyte-platelet adhesion kinetics. Thrombin and epinephrine/ADP stimulation of whole blood demonstrated that monocytes and neutrophils bind activated platelets through GMP-140, with monocytes showing a competitive advantage.
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