Key result
Thrombin-stimulated platelets selectively bind to human monocytes and polymorphonuclear leukocytes in a calcium-dependent manner, but only weakly to lymphocytes.
Thrombin stimulation induces specific, calcium-dependent binding of platelets to monocytes and PMNs, highlighting a mechanism of platelet-leukocyte interaction.
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Should not yet change practice; leaves open the role of selective, calcium-dependent platelet-leukocyte binding in human thromboinflammation.
Tw et al. (1986) studied this question. Thrombin stimulation of platelets was evaluated on Platelet-leukocyte binding. Thrombin-stimulated platelets selectively bind to human monocytes and polymorphonuclear leukocytes in a calcium-dependent manner, but only weakly to lymphocytes.
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