May 1, 1986British Journal of PharmacologyOpen Access

Effect of apamin on responses to BRL 34915, nicorandil and other relaxants in the guinea‐pig taenia caeci

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Population

guinea-pig taenia caeci

Comparison

apamin (10(-7) M) vs responses to relaxants without apamin

Design

Preclinical

Authors

SWSheila W. WeirParkside Hospital AWA.H. WestonGoethe University Frankfurt

Discussion

Member takes

Implication

Distinguishes apamin-insensitive K+ channel opening by BRL 34915 and nicorandil in animal smooth muscle; leaves open human relevance and therapeutic translation.

Structured PICO

Population

guinea-pig taenia caeci

Intervention

apamin (10(-7) M)

Comparator

responses to relaxants (BRL 34915, nicorandil, isoprenaline, ATP, noradrenaline) without apamin

Outcome

relaxation of spontaneous tone and 86Rb efflux rate coefficientsurrogate

BRL 34915 and nicorandil open potassium channels in smooth muscle via an apamin-insensitive mechanism.

Cite This Study

Weir et al. (1986) studied this question.

synapsesocial.com/papers/6a87e1aff8efd6d7e4fb1e0a https://doi.org/10.1111/j.1476-5381.1986.tb09477.x

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Implication

Distinguishes apamin-insensitive K+ channel opening by BRL 34915 and nicorandil in animal smooth muscle; leaves open human relevance and therapeutic translation.

Effect of apamin on responses to BRL 34915, nicorandil and other relaxants in the guinea‐pig taenia caeci

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of apamin on responses to BRL 34915, nicorandil and other relaxants in the guinea‐pig taenia caeci

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider