Why the study?
Does intrarenal infusion of Sar1-Ile8-angiotensin II increase urinary sodium excretion and urine flow rate in anaesthetized, dehydrated dogs?
Does intrarenal infusion of Sar1-Ile8-angiotensin II increase urinary sodium excretion and urine flow rate in anaesthetized, dehydrated dogs?
In a dehydrated dog model, endogenous angiotensin II promotes intrarenal salt and water retention, which is reversed by angiotensin II blockade.
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Endogenous intrarenal angiotensin II promotes salt and water retention during dehydration; leaves open translation to human cardiorenal syndromes.
Trippodo et al. (1977) studied this question.
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