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November 11, 2008Journal of Lipid ResearchOpen Access

PLTP activity is a risk factor for subsequent cardiovascular events in CAD patients under statin therapy: the AtheroGene Study

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Why the study?

Does serum PLTP activity predict myocardial infarction and cardiovascular death in patients with coronary artery disease?

Population

1,085 patients with angiographically documented coronary artery disease (CAD)

Design

Cohort

Follow-up

median 5.1 years

Authors

ASAxel SchlittSBStefan BlankenbergCBChristoph Bickel

Discussion

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Overview

May refine CV risk stratification in statin-treated CAD; hypothesis-generating, requires prospective validation before clinical use.

Structured PICO

Does serum PLTP activity predict myocardial infarction and cardiovascular death in patients with coronary artery disease?

P
Population
1,085 patients with angiographically documented coronary artery disease (CAD)
I
Intervention
Serum PLTP activity assessment
O
Outcome
Combined endpoint of myocardial infarction and cardiovascular deathcomposite

High plasma PLTP activity is associated with an increased risk of fatal and nonfatal cardiovascular events in CAD patients treated with statins.

Cite This Study

Schlitt et al. (2008) studied this question.

synapsesocial.com/papers/6a87edd31fec1a0b3d263bc0https://doi.org/10.1194/jlr.m800414-jlr200
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