Key result
Acute elevation of PLTP activity in a transgenic mouse model strongly increased plasma VLDL levels, destabilized atherosclerotic lesions, and aggravated pre-existing atherosclerosis.
Why the study?
Does acute elevation of plasma PLTP activity aggravate pre-existing atherosclerosis in a transgenic mouse model?
Population
Transgenic mice with a humanized lipoprotein profile and diet-induced pre-existing atherosclerosis
Comparison
Acute elevation of plasma PLTP activity via… vs Controls (mice without induced PLTP expression)
Design
Preclinical
Authors
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Acute PLTP elevation may worsen plaques amid inflammation; leaves open whether PLTP inhibition stabilizes lesions in patients.
Does acute elevation of plasma PLTP activity aggravate pre-existing atherosclerosis in a transgenic mouse model?
Acute elevation of PLTP activity, as may occur in inflammation, destabilizes atherosclerotic lesions and aggravates pre-existing atherosclerosis in a mouse model.
Moerland et al. (2008) studied Pre-existing atherosclerosis. Acute elevation of plasma PLTP activity (induced expression of human PLTP) vs. Controls was evaluated on Effects on metabolism of apolipoprotein B-containing lipoproteins and on diet-induced pre-existing atherosclerosis. Acute elevation of PLTP activity in a transgenic mouse model strongly increased plasma VLDL levels, destabilized atherosclerotic lesions, and aggravated pre-existing atherosclerosis.
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