May 13, 1997Proceedings of the National Academy of SciencesOpen Access

Voltage-controlled gating in a large conductance Ca 2+ -sensitive K + channel (hslo)

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Population

Large conductance calcium- and voltage-sensitive K+ (MaxiK) channels (hslo)

Design

Preclinical

Authors

ESEnrico StefaniMinistry of Economy, Trade and Industry MOMichela OttoliaUniversity of California, Los Angeles FNFrancesca NocetiUniversity of California, Los Angeles

Discussion

Member takes

Implication

Preclinical MaxiK data only; leaves open whether unique gating extends to human cardiovascular channels.

Structured PICO

Population

Large conductance calcium- and voltage-sensitive K+ (MaxiK) channels (hslo)

Intervention

Membrane depolarization (voltage) and micromolar internal Ca2+

Outcome

Voltage sensor rearrangements (gating currents) and pore openingsurrogate

Demonstrates that in MaxiK channels, voltage sensor movement and pore opening are triggered by voltage and facilitated by internal Ca2+, with unique charge movement properties compared to other voltage-gated channels.

Cite This Study

Stefani et al. (1997) studied this question.

synapsesocial.com/papers/6a87f3a4580ea41f0158276a https://doi.org/10.1073/pnas.94.10.5427

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Voltage-controlled gating in a large conductance Ca 2+ -sensitive K + channel (hslo)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Voltage-controlled gating in a large conductance Ca 2+ -sensitive K + channel (hslo)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider