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November 1, 1995The Journal of Infectious Diseases

Prolonged Shedding of Amantadine-Resistant Influenza A Viruses by Immunodeficient Patients: Detection by Polymerase Chain Reaction-Restriction Analysis

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Why the study?

Can PCR-restriction analysis detect amantadine-resistant influenza A viruses in immunodeficient patients?

Population

2 influenza virus-infected immunodeficient patients treated with amantadine

Design

Case_series

Authors

AKA. KlimovNational Center for Immunization and Respiratory DiseasesEREduardo P. C. RochaCenters for Disease Control and PreventionFHFrederick G. HaydenResearch Council of Finland

Discussion

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Implication

Alerts clinicians to possible prolonged resistant shedding in immunocompromised hosts; hypothesis-generating for targeted resistance surveillance.

Structured PICO

Can PCR-restriction analysis detect amantadine-resistant influenza A viruses in immunodeficient patients?

P
Population
2 influenza virus-infected immunodeficient patients treated with amantadine
I
Intervention
Polymerase chain reaction (PCR)-restriction analysis
O
Outcome
Detection of amantadine- or rimantadine-resistant strains and shedding durationsurrogate

PCR-restriction analysis enables rapid detection of amantadine-resistant influenza strains, revealing prolonged shedding in immunodeficient patients.

Cite This Study

Klimov et al. (1995) studied this question.

synapsesocial.com/papers/6a87f490010a27dee476e87ahttps://doi.org/10.1093/infdis/172.5.1352
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prophylaxis and Treatment of Influenza1990 · 211 citations
  2. 2Resistance of Influenza A Virus to Amantadine and Rimantadine: Results of One Decade of Surveillance1989 · 176 citations
  3. 3Production of the M2 protein of influenza A virus in insect cells is enhanced in the presence of amantadine1993 · 20 citations
  4. 4Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection1988 · 289 citations