March 19, 2010Blood Coagulation & Fibrinolysis

Hereditary and acquired thrombotic risk factors for chronic thromboembolic pulmonary hypertension

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Population

245 patients with pulmonary hypertension, including 45 with chronic thromboembolic pulmonary hypertension…

Design

Cohort

Authors

CWCL WongHammersmith Hospital RSRichard SzydloUppsala University SGSimon GibbsHeart Failure & Transplant

Discussion

Member takes

Implication

Factor V Leiden and elevated Factor VIII/vWF were associated with CTEPH; hypothesis-generating for thrombotic mechanisms and requires prospective validation before screening changes.

Structured PICO

Population

245 patients with pulmonary hypertension, including 45 with chronic thromboembolic pulmonary hypertension (CTEPH) and 200 with non-CTEPH.

Comparator

Patients with non-CTEPH

Outcome

Frequency of hereditary and acquired thrombotic risk factors (including factor V Leiden, antiphospholipid antibodies, factor VIII, and von Willebrand factor)surrogate

The increased prevalence of Factor V Leiden and elevated Factor VIII in CTEPH compared to non-CTEPH supports a primary role of thrombosis in the etiology of CTEPH.

Cite This Study

Wong et al. (2010) studied this question.

synapsesocial.com/papers/6a87f76e4a20e1705414b3f6 https://doi.org/10.1097/mbc.0b013e328331e664

Topics

Pulmonary embolism

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Implication

Factor V Leiden and elevated Factor VIII/vWF were associated with CTEPH; hypothesis-generating for thrombotic mechanisms and requires prospective validation before screening changes.

Hereditary and acquired thrombotic risk factors for chronic thromboembolic pulmonary hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Hereditary and acquired thrombotic risk factors for chronic thromboembolic pulmonary hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider