Successful Heparin Management Using HMS PLUS for a Patient with Endocarditis and Antiphospholipid Syndrome Undergoing Valve Replacement

71-year-old female with antiphospholipid syndrome (APS) and infective endocarditis complicated by severe mitral regurgitation and aortic regurgitation, with a history of acute myocardial infarction 3 years prior.

Heparin blood concentration management using HMS PLUS (target heparin blood concentration 3 mg/kg) during cardiopulmonary bypass for mitral and aortic valve replacement.

Successful completion of surgery without thrombotic events or circuit pressure elevation.safety