Why the study?
Do cardiovascular risk factors have differing effects on intima-media thickening and plaque formation at different sites of the arterial vasculature in older adults?
Population
792 adults aged 56-77 years recruited from two general practices participating in the British Regional Heart…
Design
Cross-sectional
Authors
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Risk factor associations with IMT and plaque vary by arterial site; leaves open whether site-specific surrogates improve trial validity in older adults.
Do cardiovascular risk factors have differing effects on intima-media thickening and plaque formation at different sites of the arterial vasculature in older adults?
The associations of cardiovascular risk factors with vascular anatomy are not uniform, suggesting that local arterial anatomy differences may impact trial outcomes investigating surrogate endpoints like IMT.
Chaubey et al. (2010) studied this question.
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