What question did this study set out to answer?

To assess the therapeutic outcomes of long-term growth hormone replacement in growth hormone-deficient adults and determine whether circulating IGF-I levels accurately monitor and predict clinical efficacy.

December 1, 2003European Journal of Endocrinology

Circulating IGF-I levels in monitoring and predicting efficacy during long-term GH treatment of GH-deficient adults

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Authors

SEShereen EzzatPrincess Margaret Cancer Centre SFSimon FearRoche (Switzerland)GRGaillard RcUniversity Hospital of Lausanne

Discussion

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Implication

Interventional study reveals sustained growth hormone therapy improves body composition and cardiac health in deficient adults, indicating IGF-I selectively tracks lean mass gains.

Key Points

To assess the therapeutic outcomes of long-term growth hormone replacement in growth hormone-deficient adults and determine whether circulating IGF-I levels accurately monitor and predict clinical efficacy.
Adult patients with growth hormone deficiency received growth hormone at 5 µg/kg per day for 1 month, followed by 10 µg/kg per day for 12 to 30 months.
Investigators tracked longitudinal changes in body composition, echocardiographic cardiac structure and function, serum lipid profiles, and quality of life.
Lean body mass increased by 2.21 kg (P<0.0001) after 6 months—with greater increases in males than females (2.97 vs 1.19 kg; P<0.0001)—and total fat mass decreased by 2.56 kg (P<0.0001), with lean mass gains significantly correlating with IGF-I changes (P<0.004).
Cardiac ejection fraction increased by 3.85 ± 9.95% after 6 months (P=0.0002) and remained elevated through 18 months equally across sexes, while serum LDL/HDL ratios and quality of life showed sustained improvements without correlating with circulating IGF-I levels.

Cite This Study

Ezzat et al. (2003) studied this question.

synapsesocial.com/papers/6a87fb31d79ae02bd34de9be https://doi.org/10.1530/eje.0.1490499

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Implication

Interventional study reveals sustained growth hormone therapy improves body composition and cardiac health in deficient adults, indicating IGF-I selectively tracks lean mass gains.

Circulating IGF-I levels in monitoring and predicting efficacy during long-term GH treatment of GH-deficient adults

Discussion

Member takes

Implication

Key Points

Cite This Study

Circulating IGF-I levels in monitoring and predicting efficacy during long-term GH treatment of GH-deficient adults

Discussion

Member takes

Implication

Key Points

Cite This Study

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