Why the study?
Does vitamin E deficiency affect platelet aggregation and platelet count in rats?
Population
Rats (evaluated at 9-10 weeks and 15 weeks of deficiency)
Comparison
Vitamin E deficiency vs Control animals
Design
Preclinical
Follow-up
15 weeks
Authors
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Potential prothrombotic effect in vitamin E deficiency; leaves open translation to human platelet function or supplementation.
Does vitamin E deficiency affect platelet aggregation and platelet count in rats?
Vitamin E deficiency in rats leads to increased collagen-induced platelet aggregation and, with prolonged deficiency, elevated platelet counts.
Machlin et al. (1975) studied this question.
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