Population
Rat model for in vivo platelet aggregation
Design
Preclinical
Authors
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NSAIDs yield only partial in vivo platelet inhibition despite full TXA2 blockade; leaves open multi-pathway mechanisms in animal models.
In vivo collagen-induced platelet aggregation involves multiple independent pathways dependent on extracellular divalent cations, which are only partially inhibited by NSAIDs.
Mallarkey et al. (1984) studied this question.
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