Why the study?
Does Salmonella typhimurium endotoxin produce hypertriglyceridemia and impair lipid disposal mechanisms in male rhesus monkeys?
Population
70 male rhesus monkeys
Design
Preclinical
Follow-up
8 hours
Authors
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Raises caution for lipid handling during primate infection; leaves open translation to human sepsis management.
Does Salmonella typhimurium endotoxin produce hypertriglyceridemia and impair lipid disposal mechanisms in male rhesus monkeys?
Endotoxin significantly elevates serum triglyceride concentrations and impairs lipid disposal mechanisms by interfering with the activation of lipid-clearing enzymes in a primate model.
Kaufmann et al. (1976) studied this question.
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