In PA-nephrotic rats, urinary excretion of angiotensinogen and renin may explain their respective low plasma levels and limited increase in plasma renin activity.
Sequential urinary angiotensinogen and renin in nephrotic rats; leaves open their role in human proteinuric RAS dysregulation.
Puromycin aminonucleoside (PA)-nephrotic rats have a high plasma renin activity (PRA) and low angiotensinogen levels. We measured proteinuria, urine renin, and urine angiotensinogen daily, for 11 days after PA injection. Proteinuria and urine angiotensinogen were evident on day 5, and urine renin on day 6. Peak levels of urine renin and angiotensinogen were attained on day 8. These data suggest that angiotensinogen urine excretion may contribute to its low plasma levels, and urine renin loss may limit a further increase in PRA.
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Pedraza‐Chaverrí et al. (2008) studied this question.
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