Why the study?
Does the addition of Skp2 to D1NLS and CDK4 improve cardiomyocyte regeneration and post-ischaemic cardiac performance in a rat model of ischaemia/reperfusion injury?
Population
Wistar rats undergoing ischaemia/reperfusion injury by ligation of the coronary artery
Comparison
Injection of adenovirus vectors for D1NLS and… vs Injection of adenovirus vectors for D1NLS and…
Design
Preclinical
Authors
Loading...
Hypothesis-generating for Skp2-augmented cardiomyocyte proliferation post-ischaemia in rats; leaves open translation to human cardiac repair.
Does the addition of Skp2 to D1NLS and CDK4 improve cardiomyocyte regeneration and post-ischaemic cardiac performance in a rat model of ischaemia/reperfusion injury?
Skp2 enhances the proliferative effect of cyclins on cardiomyocytes and improves post-ischaemic cardiac function in vivo.
Tamamori‐Adachi et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: