Why the study?
Do endogenous opioids modulate baroreflex control of blood pressure in normal humans?
Population
16 normal human subjects across two studies (n=9 in study 1, n=7 in study 2)
Comparison
Infusions of DAMME or naloxone vs Saline or placebo infusion
Design
Other
Follow-up
6 hours
Authors
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Hypothesis-generating in healthy subjects; leaves open clinical relevance or therapeutic targeting in hypertension.
Do endogenous opioids modulate baroreflex control of blood pressure in normal humans?
Endogenous opioids modulate the baroreflex control of blood pressure in normal humans, as evidenced by altered hemodynamic responses to tilt and nitroprusside with opioid agonism and antagonism.
Rubin et al. (1983) studied this question.
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