Why the study?
Does candesartan improve heart rate variability and baroreflex sensitivity in patients with heart failure not on ACE inhibitors?
Population
21 patients with heart failure, mean ejection fraction 33%, in the absence of angiotensin-converting enzyme…
Comparison
Candesartan 8 mg orally for acute assessment… vs Placebo
Design
RCT, randomized cross-over, double-blind
Follow-up
4 weeks
Authors
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Unlike ACE inhibitors, candesartan does not improve heart rate variability in heart failure; challenges assumed class equivalence on autonomic modulation.
Does candesartan improve heart rate variability and baroreflex sensitivity in patients with heart failure not on ACE inhibitors?
In contrast to ACE inhibitors, angiotensin II receptor blockade with candesartan in heart failure does not increase heart rate variability and has inconsistent effects on baroreflex sensitivity.
Vaile et al. (2001) studied this question.
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