September 1, 1990The Journal of PhysiologyOpen Access

GTP‐binding proteins mediate noradrenaline effects on calcium and chloride currents in rat portal vein myocytes.

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Population

Cultured cells from rat portal vein myocytes

Design

Preclinical

Authors

Discussion

Hypothesis-generating in rat myocytes; requires human validation before any clinical relevance.

Population

Cultured cells from rat portal vein myocytes

Intervention

Noradrenaline (10(-5) M) and various modulators (PDBu, GDP-beta-S, GTP-gamma-S, pertussis toxin)

Outcome

Membrane currents (voltage-dependent inward current and calcium-activated chloride current)surrogate

In rat portal vein myocytes, noradrenaline modulates calcium and chloride currents via a pertussis toxin-insensitive GTP-binding protein pathway.

Loirand et al. (1990) studied this question.

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