A comparative evaluation of adipokine VASPIN in female obese and non-obese subjects with periodontitis and health

Introduction: Periodontitis and obesity are major health hazards. Adiposity stimulates cytokines which aggravate periodontitis. To balance this body secretes an anti-inflammatory adipokine-like visceral adipose tissue-derived serine protease inhibitor (VASPIN). Aims and Objectives: The study aimed to assess serum VASPIN levels in females with and without periodontitis, categorized by obesity status. Materials and Methods: Eighty female subjects with the age range of 35–44 years were included in this observational study. All have been categorized into four groups, 20 in each group. The division was based on the body mass index (BMI) and Russell's Periodontal Index (PI). Group I-with BMI 18.5–24.9 kg/m 2 ; without PD (non-obese without PD) Group II-with BMI 25-29.9 kg/m 2 ; with PD (non-obese with PD). Group III -with BMI ≥30 kg/m 2 ; without PD (obese without PD).Group IV with BMI ≥30 kg/m 2 ; with PD (Obese with PD). Statistics Used: Serum VASPIN levels were compared in all the groups. Among the groups were analyzed with ANOVA, Bartlett's test for homogeneity of variances, and Bonferroni test for multiple comparisons. Results: When VASPIN and BMI were correlated, higher levels were found in Group II, followed by Groups IV, III, and I. Serum VASPIN levels among the groups were statistically significant P < 0.0001. Conclusion: Serum VASPIN can be used for predicting the progression of periodontal inflammation associated with obesity and also can act as a good biomarker for the initial stages of obesity.