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January 14, 2011StrokeOpen Access

Biomarkers of Asymptomatic Carotid Stenosis in Patients Undergoing Coronary Artery Bypass Grafting

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Why the study?

Are plasma levels of apoB/apoA-I, lipoprotein(a), and homocysteine associated with asymptomatic carotid stenosis in patients undergoing coronary artery bypass surgery?

Population

757 patients aged ≥50 years undergoing nonemergency coronary artery bypass surgery, excluding those with…

Comparison

Plasma levels of apolipoprotein B:apoA-I… vs Lowest quartile of respective biomarkers

Design

Cross-sectional

Authors

SKSuk Jae KimPSPamela SongJPJae Hyun Park

Discussion

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Overview

Associations should not change practice in CABG patients; hypothesis-generating for prospective validation of progression and events.

Structured PICO

Are plasma levels of apoB/apoA-I, lipoprotein(a), and homocysteine associated with asymptomatic carotid stenosis in patients undergoing coronary artery bypass surgery?

P
Population
757 patients aged ≥50 years undergoing nonemergency coronary artery bypass surgery, excluding those with previous stroke or transient ischemic attack.
I
Intervention
Plasma levels of apolipoprotein B (apoB):apoA-I, lipoprotein(a), and homocysteine
C
Comparator
Lowest quartile of respective biomarkers
O
Outcome
Presence of asymptomatic carotid stenosis ≥50% and ≥70% on preoperative duplex scanningsurrogate

Elevated plasma levels of apoB/apoA-I, lipoprotein(a), and homocysteine are independent predictors of asymptomatic carotid stenosis in patients undergoing coronary artery bypass grafting.

Cite This Study

Kim et al. (2011) studied this question.

synapsesocial.com/papers/6a880daeab77196d53aa68dfhttps://doi.org/10.1161/strokeaha.110.595546
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lipids and carotid plaque in the Northern Manhattan Study (NOMAS)2009 · 61 citations
  2. 2Staged carotid artery stenting and coronary artery bypass graft surgery: Initial results from a single center2005 · 36 citations
  3. 3Apolipoprotein B/Apolipoprotein A-I in Relation to the Metabolic Syndrome and Change in Carotid Artery Intima-Media Thickness During 3 Years in Middle-Aged Men2004 · 126 citations
  4. 4Lipoprotein (a) and stroke: Table 12000 · 122 citations
  5. 5Association of Plasma Homocysteine Concentration With Atherosclerotic Carotid Plaques and Lacunar Infarction2002 · 67 citations