Population
Mouse models with conditionally altered Notch signalling in endothelial or interstitial cells of developing…
Comparison
Inactivation or activation of Notch1 signalling vs Control/wild-type models (implied)
Design
Preclinical
Authors
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Should not change BAV management; leaves open translational relevance of Notch-Tnf in humans.
Notch-Tnf signalling is critical for the post-EMT development of arterial valves, and its disruption leads to congenital anomalies like bicuspid aortic valves in animal models.
Wang et al. (2015) studied this question.
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