Greater Change of Orthostatic Blood Pressure Is Related to Silent Cerebral Infarct and Cardiac Overload in Hypertensive Subjects
Why the study?
Are greater changes in orthostatic blood pressure associated with silent cerebral infarcts and cardiac overload in hypertensive subjects?
Population
86 subjects, comprising 59 hypertensive patients and 27 normotensive controls.
Comparison
Orthostatic blood pressure changes assessed via… vs Orthostatic normotension and normotensive…
Design
Cross-sectional
Authors
Discussion
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Implication
Exaggerated orthostatic BP changes were associated with cardiac overload and SCI in hypertension; leaves open causal links and need for prospective outcome trials.
Structured PICO
Are greater changes in orthostatic blood pressure associated with silent cerebral infarcts and cardiac overload in hypertensive subjects?
P
Population
86 subjects, comprising 59 hypertensive patients and 27 normotensive controls.
I
Intervention
Orthostatic blood pressure changes (orthostatic hypertension [OHT, n=16] or orthostatic hypotension [OHYPO, n=18]) assessed via head-up tilting test.
C
Comparator
Orthostatic normotension (ONT, n=25) and normotensive controls (NT, n=27).
O
Outcome
Plasma atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels, and presence/number of silent cerebral infarcts (SCI) on brain MRI.surrogate
Hypertensive patients with exaggerated orthostatic blood pressure changes (both hypertension and hypotension) have an increased risk of silent brain lesions and greater cardiac burden.
Cite This Study
Kario et al. (2004) studied this question.