Altered Aortic Properties in Elderly Orthostatic Hypertension
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Key result
Elderly hypertensive patients with orthostatic hypertension had a significantly greater orthostatic augmentation index compared to those with orthostatic normotension (6.5% vs -5.6%, p<0.001).
Population
365 older hypertensive patients from two Japanese hospital clinics. Classified into orthostatic hypertension…
Design
Cross-sectional
Authors
Discussion
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Implication
Orthostatic hypertension may reflect augmented wave reflection in elderly patients; hypothesis-generating for mechanisms and interventions without practice implications.
Study Design
Type
Cross-Sectional (n=365)
Multicenter
Yes
Structured PICO
P
Population
365 older hypertensive patients were evaluated in a cross-sectional study to investigate the relationship between aortic properties and orthostatic blood pressure dysregulation.
O
Outcome
Orthostatic change in augmentation index (AI) and pulse wave velocity (PWV)surrogate
Main Result
Absolute Event Rate: 6.5% vs -5.6%
p-value: p=<0.001
Orthostatic hypertension in older patients is associated with augmented wave reflection of arterial pressure rather than increased arterial stiffness.
Limitations
- Cross-sectional design limits causal inference
- Potential confounding by anti-hypertensive medications such as alpha-blockers and calcium antagonists
- High prevalence of diabetes mellitus in the orthostatic hypertension group may have influenced results
Cite This Study
Hoshide et al. (2005) conducted a cross-sectional in Orthostatic hypertension in elderly hypertensives (n=365). Orthostatic hypertension (OHT) vs. Orthostatic normotension (ONT) was evaluated on Orthostatic augmentation index (AI) change (p=<0.001). Elderly hypertensive patients with orthostatic hypertension had a significantly greater orthostatic augmentation index compared to those with orthostatic normotension (6.5% vs -5.6%, p<0.001).
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