Population
Cultured neonatal mouse cardiac myocytes and cultured neonatal rat cardiac myocytes
Comparison
Hypertrophic stimuli including triiodothyronine… vs Untreated cells and rat myocytes
Design
Preclinical
Authors
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Species differences in myocyte hypertrophy responses warrant model-specific caution; leaves open optimal platforms for human-relevant translational studies.
Neonatal mouse cardiac myocytes exhibit unique autonomous hypertrophy and distinct responses to hypertrophic stimuli compared to rat myocytes, highlighting important species differences for basic science models of cardiac hypertrophy.
Deng et al. (2000) studied this question.
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