Key result
Incubating pure cardiomyocytes in non-myocyte cell-conditioned growth medium for 72 hours decreased Ito density by 42% and reduced Kv4.2 K+ channel protein levels by 36%.
Paracrine hypertrophic factors from cardiac non-myocyte cells downregulate transient outward K+ current density and Kv4.2 channel expression in cardiomyocytes, contributing to electrophysiological remodeling in cardiac hypertrophy.
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NMCs may modulate Ito and APD in neonatal rat MC hypertrophy models; leaves open in vivo relevance or therapeutic targeting.
Wei Guo (1999) studied Cardiac hypertrophy. NMC-conditioned growth medium (NCGM) or MC-NMC co-culture vs. Pure MC culture was evaluated on Ito density and Kv4.2 K+ channel protein level. Incubating pure cardiomyocytes in non-myocyte cell-conditioned growth medium for 72 hours decreased Ito density by 42% and reduced Kv4.2 K+ channel protein levels by 36%.
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