Involvement of Cardiotrophin-1 in Cardiac Myocyte-Nonmyocyte Interactions During Hypertrophy of Rat Cardiac Myocytes In Vitro
Population
In vitro coculture system of rat cardiac myocytes and nonmyocytes
Design
Preclinical
Authors
Discussion
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Member takes
Implication
CT-1 identified as local regulator of myocyte hypertrophy; leaves open in vivo validation and clinical translation.
Structured PICO
P
Population
In vitro coculture system of rat cardiac myocytes and nonmyocytes
I
Intervention
Anti-CT-1 antibodies, non-myocyte-conditioned medium, CT-1, and endothelin-1
O
Outcome
Hypertrophic changes including atrial and brain natriuretic peptide secretion, protein synthesis, and tyrosine phosphorylation of STAT3surrogate
CT-1 secreted from cardiac nonmyocytes plays a significant role in inducing hypertrophic changes in cardiac myocytes, suggesting it is an important local regulator of cardiac hypertrophy.
Cite This Study
Kuwahara et al. (1999) studied this question.