Key result
Exogenous delivery of human cardiotrophin 1 induced reversible, physiologic cardiac hypertrophy and improved contractile function in a severe rodent model of right heart failure.
Why the study?
Does human cardiotrophin 1 (hCT1) induce beneficial physiologic hypertrophy and improve cardiac function in rodent models?
Does human cardiotrophin 1 (hCT1) induce beneficial physiologic hypertrophy and improve cardiac function in rodent models?
Exogenous cardiotrophin 1 induces reversible, physiologic cardiac hypertrophy and restores contractile function in a preclinical model of right heart failure.
No takes yet. Share an insight, caveat, or question.
Should not yet change practice; leaves open translation of hCT1-induced hypertrophy to human right heart failure.
Abdul‐Ghani et al. (2017) studied Right heart failure and cardiac hypertrophy. Human cardiotrophin 1 (hCT1) vs. PBS, phenylephrine (PE), or isoproterenol (ISO) was evaluated on Cardiac remodeling, contractile function, and structural dimensions. Exogenous delivery of human cardiotrophin 1 induced reversible, physiologic cardiac hypertrophy and improved contractile function in a severe rodent model of right heart failure.
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