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May 1, 1990Journal of Biological ChemistryOpen Access

Differential activation of protein kinase C alpha is associated with arachidonate release in Madin-Darby canine kidney cells.

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Population

Madin-Darby canine kidney (MDCK) cells

Design

Preclinical

Authors

CGCatherine GodsonUniversity College DublinPIPaul A. InselHeart Failure & Transplant

Discussion

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Implication

Supports PKCα mediation of arachidonate release in MDCK cells; leaves open relevance to human cardiovascular disease.

Structured PICO

P
Population
Madin-Darby canine kidney (MDCK) cells
I
Intervention
Stimulation with bradykinin, phorbol ester, and dioctanoylglycerol; down-regulation of PKC alpha
O
Outcome
Arachidonate (AA) releasesurrogate

The PKC alpha isoform is likely responsible for mediating arachidonate release in MDCK cells.

Cite This Study

Godson et al. (1990) studied this question.

synapsesocial.com/papers/6a8810fcab77196d53aa69d7https://doi.org/10.1016/s0021-9258(19)38894-5
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Also Consider

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  1. 1PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,692 citations
  2. 2Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells.1986 · 192 citations
  3. 3Alpha 1-adrenergic receptors promote phosphatidylcholine hydrolysis in MDCK-D1 cells. A mechanism for rapid activation of protein kinase C.1988 · 115 citations
  4. 4Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.1979 · 53,817 citations
  5. 5Limited Proteolysis of Protein Kinase C Subspecies by Calcium-dependent Neutral Protease (Calpain)1989 · 472 citations