Population
Rat outer medullary collecting duct (OMCD) tubules
Comparison
ANG II, NH4Cl ingestion, or Deoxycorticosterone… vs NaHCO3 ingestion, no treatment, or AT1 receptor…
Design
Preclinical
Follow-up
7 days (for drinking water treatments)
Authors
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Should not guide clinical acidosis management; leaves open relevance of this ANG II effect in humans.
Increased circulating ANG II, as occurs during metabolic acidosis, paradoxically reduces net acid secretion in the rat outer medullary collecting duct.
Wall et al. (2003) studied this question.
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