Population
in vitro microperfused rabbit cortical collecting duct (CCD) segments
Comparison
Angiotensin II 10 M or 10 M added to peritubular… vs Vehicle or ANG II + losartan 10(-6) M
Design
Preclinical
Follow-up
30 min
Authors
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No immediate clinical implications for acid-base disorders; leaves open translational relevance of AT1 effects on tubular transport.
Angiotensin II stimulates luminal alkalinization in the outer cortical collecting duct via basolateral AT1 receptors, partly through B cell stimulation.
Weiner et al. (1995) studied this question.
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