What question did this study set out to answer?

To identify the anatomical sites and clinical severity of cardiac conduction defects in patients with aortic stenosis.

September 1, 1977Annals of Internal Medicine

Sites of Conduction Disease in Aortic Stenosis

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Population

32 patients with aortic stenosis

Comparison

Electrophysiologic studies vs Internal comparisons based on presence of valve…

Design

Cross-sectional

Authors

DRDhingra RcUniversity of Illinois Chicago FAF Amat-y-LeonUnited States Department of Veterans Affairs CWChristopher R.C. WyndhamEast Sussex County Council

Discussion

Member takes

Implication

Calcific aortic stenosis with higher gradients was associated with prolonged H-V intervals; hypothesis-generating for conduction disease but should not yet change practice.

Key Points

To identify the anatomical sites and clinical severity of cardiac conduction defects in patients with aortic stenosis.
Performed electrophysiologic studies evaluating A-H and H-V intervals in 32 patients with aortic stenosis.
Assessed conduction abnormalities in subgroups categorized by presence of valve calcification and aortic pressure gradients (threshold of 40 mm Hg).
In 24 patients with intact A-V conduction, mean H-V intervals were significantly longer in those with calcific aortic stenosis (63 ± 2.6 msec) than in those without calcification (50 ± 4.9 msec, P < 0.05).
Mean H-V intervals were significantly increased in patients with transvalvular gradients > 40 mm Hg (62 ± 5.6 msec) compared to those with gradients < 40 mm Hg (47 ± 3.1 msec, P < 0.05).
Among eight patients with complete A-V block, conduction failure occurred within the His bundle (n = 5) or distal to it (n = 3), and all eight had calcified valves.

Structured PICO

Population

32 patients with aortic stenosis

Intervention

Electrophysiologic studies

Comparator

Internal comparisons based on presence of valve calcification and aortic gradient severity

Outcome

A-H intervals, H-V intervals, and site of A-V blocksurrogate

Aortic stenosis, particularly when associated with valve calcification and higher gradients, is frequently linked to latent and manifest conduction disease in the His bundle and trifascicular system.

Cite This Study

Rc et al. (1977) studied this question.

synapsesocial.com/papers/6a8818436304c7fd8e4df238 https://doi.org/10.7326/0003-4819-87-3-275

Topics

Valvular heart disease

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Implication

Calcific aortic stenosis with higher gradients was associated with prolonged H-V intervals; hypothesis-generating for conduction disease but should not yet change practice.

Sites of Conduction Disease in Aortic Stenosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Sites of Conduction Disease in Aortic Stenosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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