Key result
Chronic thromboembolic disease without pulmonary hypertension and CTEPH were associated with prolonged right ventricular diastolic relaxation compared to controls (tau 69.7 and 67.9 vs 56.2 ms, P=0.02).
Why the study?
Does right ventricular conductance catheterization detect differences in right ventricular mechanics in patients with chronic thromboembolic obstruction compared to controls?
Cross-Sectional (n=24)
No
Does right ventricular conductance catheterization detect differences in right ventricular mechanics in patients with chronic thromboembolic obstruction compared to controls?
Absolute Event Rate: 69.7% vs 56.2%
p-value: p=0.02
Conductance catheterization detects delayed right ventricular relaxation and altered pressure-volume loop morphology in patients with chronic thromboembolic disease without pulmonary hypertension, distinguishing them from controls.
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May indicate early RV diastolic impairment before PH; hypothesis-generating for conductance catheterization in risk stratification.
McCabe et al. (2013) conducted a cross-sectional in Chronic thromboembolic obstruction of the pulmonary artery (CTEPH and CTED) (n=24). Chronic thromboembolic obstruction vs. Controls (structurally normal heart) was evaluated on Diastolic relaxation time constant (tau) (p=0.02). Chronic thromboembolic disease without pulmonary hypertension and CTEPH were associated with prolonged right ventricular diastolic relaxation compared to controls (tau 69.7 and 67.9 vs 56.2 ms, P=0.02).
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