Key result
Female sex was not associated with a significantly different risk of major adverse cardiovascular events compared to male sex in patients with chronic coronary syndrome after percutaneous coronary intervention (HR 1.20).
Why the study?
Prior findings regarding sex differences in long-term outcomes among patients with chronic coronary syndrome were inconsistent.
Does female sex affect the incidence of major adverse cardiovascular events in patients with chronic coronary syndrome after percutaneous coronary intervention?
Cohort (n=5,555)
Yes
Does female sex affect the incidence of major adverse cardiovascular events in patients with chronic coronary syndrome after percutaneous coronary intervention?
Hazard Ratio: 1.2 (95% CI 0.97–1.47)
Absolute Event Rate: 9.9% vs 8.9%
p-value: p=0.087
In a Japanese real-world cohort of patients with chronic coronary syndrome undergoing PCI, there were no significant sex differences in long-term major adverse cardiovascular events after adjusting for confounding factors.
BACKGROUND: Several studies have reported some sex differences in patients with coronary artery diseases. However, the results regarding long-term outcomes in patients with chronic coronary syndrome (CCS) are inconsistent. Therefore, the present study investigated sex differences in long-term outcomes in patients with CCS after percutaneous coronary intervention (PCI). METHODS AND RESULTS: This was a retrospective, multicenter cohort study. We enrolled patients with CCS who underwent PCI between April 2013 and March 2019 using the Clinical Deep Data Accumulation System (CLIDAS) database. The primary outcome was major adverse cardiovascular events (MACE), defined as a composite of cardiovascular death, non-fatal myocardial infarction, or hospitalization for heart failure. In all, 5,555 patients with CCS after PCI were included in the analysis (4,354 (78.4%) men, 1,201 (21.6%) women). The median follow-up duration was 917 days (interquartile range 312-1,508 days). The incidence of MACE was not significantly different between the 2 groups (hazard ratio [HR] 1.20; 95% confidential interval [CI] 0.97-1.47; log-rank P=0.087). After performing multivariable Cox regression analyses on 4 different models, there were still no differences in the incidence of MACE between women and men. CONCLUSIONS: There were no significant sex differences in MACE in patients with CCS who underwent PCI and underwent multidisciplinary treatments.
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Akashi et al. (2023) conducted a cohort in Chronic coronary syndrome (CCS) after percutaneous coronary intervention (PCI) (n=5,555). Female sex vs. Male sex was evaluated on Major adverse cardiovascular events (MACE), defined as a composite of cardiovascular death, non-fatal myocardial infarction, or hospitalization for heart failure (HR 1.20, 95% CI 0.97-1.47, p=0.087). Female sex was not associated with a significantly different risk of major adverse cardiovascular events compared to male sex in patients with chronic coronary syndrome after percutaneous coronary intervention (HR 1.20).
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