Key result
Extracellular acidification from pH 7.4 to 6.4 reversibly increased intracellular free magnesium concentration by 0.36 mM in guinea pig papillary muscles.
Mean Difference: 0.36
Changes in intracellular and extracellular pH inversely modulate intracellular free magnesium concentrations in guinea pig papillary muscle, likely affecting intracellular magnesium homeostasis rather than sarcolemmal transport.
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Hypothesis-generating for pH-Mg2+ interactions in cardiac muscle; no implications for clinical practice.
Kim et al. (2006) studied Normal cardiac physiology (animal model). Extracellular and intracellular pH modulation vs. pH 7.4 was evaluated on Change in intracellular Mg2+ concentration ([Mg2+]i) (increase by 0.36 mM). Extracellular acidification from pH 7.4 to 6.4 reversibly increased intracellular free magnesium concentration by 0.36 mM in guinea pig papillary muscles.
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