Population
Intact and skinned muscle tissues of the rabbit mesenteric artery
Comparison
12-o-tetradecanoylphorbol-13-acetate with or… vs Control conditions without TPA
Design
Preclinical
Authors
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PKC activation may enhance vascular tone beyond MLC20 phosphorylation; hypothesis-generating for vasomotor disorders, requiring human validation.
Protein kinase C activation by TPA enhances vascular smooth muscle contraction through both MLC20 phosphorylation-dependent and independent regulatory processes.
Fujiwara et al. (1988) studied this question.
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