Why the study?
Does phorbol myristate acetate alter contractile state and calcium flux in cultured chick ventricular cells?
Population
Spontaneously contracting cultured chick ventricular cells
Comparison
Phorbol myristate acetate at concentrations up… vs Control and phorbol didecanoate (1 microM)
Design
Preclinical
Authors
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PMA effects in chick cells warrant caution before human extrapolation; leaves open PKC modulation of myocardial calcium homeostasis.
Does phorbol myristate acetate alter contractile state and calcium flux in cultured chick ventricular cells?
PMA decreases contractile amplitude and cytosolic free calcium in cultured chick ventricular cells, suggesting protein kinase C modulates myocardial calcium homeostasis.
Leatherman et al. (1987) studied this question.