Key result
Phorbol esters caused a negative chronotropic effect and significantly decreased the maximum rate of depolarization by 46.7% and action potential amplitude by 13.9% in embryonic chick cardiomyocytes.
Effect estimate: 46.7% decrease
p-value: p=<0.01
Protein kinase C stimulation by phorbol esters depresses spontaneous activity and modulates ionic currents in embryonic chick cardiomyocytes.
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Should not guide clinical decisions; leaves open PKC effects on cardiac electrophysiology for translational studies.
Hiroyasu Satoh (1995) studied Embryonic chick ventricular cardiomyocytes. Phorbol esters (PDB and TPA) vs. Baseline (normal Tyrode's solution) was evaluated on Maximum rate of depolarization (Vmax) (46.7% decrease, p=<0.01). Phorbol esters caused a negative chronotropic effect and significantly decreased the maximum rate of depolarization by 46.7% and action potential amplitude by 13.9% in embryonic chick cardiomyocytes.
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