What question did this study set out to answer?

To test whether cardiac nerves modulate the dynamic rate of adaptation during coronary metabolic vasodilatation and autoregulation.

December 1, 1999Cardiovascular ResearchOpen Access

Chronic cardiac denervation affects the speed of coronary vascular regulation

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Why the study?

Does chronic cardiac denervation affect the speed of coronary vascular regulation in dogs?

Population

14 anaesthetised dogs (7 innervated control and 7 with denervated hearts)

Comparison

Chronic cardiac denervation vs Innervated (control) hearts

Design

Preclinical

Authors

IVIsabelle VergroesenAmsterdam UMC Location University of Amsterdam

Discussion

Member takes

Implication

Cardiac innervation modulates coronary response kinetics in dogs; hypothesis-generating for denervation effects on human vascular regulation.

Key Points

To test whether cardiac nerves modulate the dynamic rate of adaptation during coronary metabolic vasodilatation and autoregulation.
Studied 14 anesthetized dogs divided into innervated controls (n=7) and chronically denervated heart models (n=7).
Subjected subjects to controlled pressure perfusion of the left main coronary artery while maintaining heart rate via pacing.
Steady-state metabolic regulation and autoregulation response curves were similar between innervated and denervated groups.
Abrupt heart rate changes produced a faster response in innervated dogs than denervated dogs, with 22% shorter half-times (P < 0.001).
Abrupt coronary arterial perfusion pressure changes produced a slower response in innervated hearts than denervated hearts, with 24% longer half-times (P < 0.005).

Structured PICO

Does chronic cardiac denervation affect the speed of coronary vascular regulation in dogs?

Population

14 anaesthetised dogs (7 innervated control and 7 with denervated hearts)

Intervention

Chronic cardiac denervation

Comparator

Innervated (control) hearts

Outcome

Rate of adaptation of coronary metabolic vasodilatation and autoregulation (response half-times to sudden changes in heart rate or perfusion pressure)surrogate

Cardiac nerves modulate the speed of coronary vascular regulation, reinforcing metabolic vasodilatation during heart rate increases and opposing vasoconstriction during increased perfusion pressure.

Cite This Study

Isabelle Vergroesen (1999) studied this question.

synapsesocial.com/papers/6a882a57fc0635f4eccf0a74 https://doi.org/10.1016/s0008-6363(99)00257-6

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Implication

Cardiac innervation modulates coronary response kinetics in dogs; hypothesis-generating for denervation effects on human vascular regulation.

Chronic cardiac denervation affects the speed of coronary vascular regulation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Chronic cardiac denervation affects the speed of coronary vascular regulation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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