What is the clinical evidence from this study?

Study design: Review. Population: Hypertension. Intervention: Diuretics vs. Placebo or control. Primary outcome: Cardiovascular morbidity and mortality.

What question did this study set out to answer?

To review the effects of diuretic-based antihypertensive regimens on cardiovascular morbidity, mortality, and clinical outcomes.

November 18, 2008Cardiology

Effect of Diuretics on Morbidity and Mortality in the Treatment of Hypertension

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Key result

Diuretic-based hypertension treatment reduced cardiovascular morbidity and mortality, including stroke and coronary heart disease events, compared with placebo or control.

Why the study?

Does diuretic-based treatment reduce cardiovascular morbidity and mortality in patients with hypertension?

Population

Patients with hypertension

Comparison

Diuretic-based treatment vs Placebo or control

Design

Review

Authors

MMMarvin MoserUniversity of London

Discussion

Member takes

Implication

Supports diuretic preference in hypertension; leaves open optimal comparisons with contemporary agents.

Key Points

To review the effects of diuretic-based antihypertensive regimens on cardiovascular morbidity, mortality, and clinical outcomes.
Evaluation of diuretic-based hypertension clinical trials comparing active treatment with placebo or control groups.
Assessment of clinical outcomes including fatal and non-fatal stroke, coronary heart disease events, congestive heart failure, and progression of hypertension.
Diuretic-based regimens universally reduced cardiovascular morbidity and mortality, including significant reductions in fatal and non-fatal stroke and coronary heart disease events.
Treatment prevented congestive heart failure, reversed left ventricular hypertrophy, and reduced progression to more severe hypertension.
Suspected adverse effects on lipid and glucose metabolism were not found to offset the clinical benefits of blood pressure reduction.

Structured PICO

Does diuretic-based treatment reduce cardiovascular morbidity and mortality in patients with hypertension?

Population

Patients with hypertension

Intervention

Diuretic-based treatment

Comparator

Placebo or control

Outcome

Cardiovascular morbidity and mortalityhard clinical

Diuretics remain a preferred initial therapy for hypertension due to their proven efficacy in reducing cardiovascular morbidity, mortality, and related complications.

Cite This Study

Marvin Moser (2008) conducted a review in Hypertension. Diuretics vs. Placebo or control was evaluated on Cardiovascular morbidity and mortality. Diuretic-based hypertension treatment reduced cardiovascular morbidity and mortality, including stroke and coronary heart disease events, compared with placebo or control.

synapsesocial.com/papers/6a882b22c16cbaca05f4cecb https://doi.org/10.1159/000176454

Topics

Hypertension management

View Full Paper

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Effect of Diuretics on Morbidity and Mortality in the Treatment of Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Effect of Diuretics on Morbidity and Mortality in the Treatment of Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider