March 1, 1999Diagnostic Molecular Pathology
Enteroviral Genome in Native Hearts May Influence Outcome of Patients Who Undergo Cardiac Transplantation
Why the study?
Does the presence of Enteroviral genome in native hearts influence post-transplantation outcomes in patients undergoing cardiac transplantation?
Population
45 explanted hearts from patients who underwent orthotopic heart transplant at University of Padova.
Comparison
Detection of Enterovirus genome in native hearts… vs Patients without Enterovirus positivity in…
Design
Cohort
Authors
Discussion
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Implication
Enteroviral genome in native hearts was associated with severe rejection or recurrence in 2 cases; hypothesis-generating and requires validation before clinical consideration.
Structured PICO
Does the presence of Enteroviral genome in native hearts influence post-transplantation outcomes in patients undergoing cardiac transplantation?
P
Population
45 explanted hearts from patients who underwent orthotopic heart transplant at University of Padova (27 dilated cardiomyopathy, 12 ischemic cardiopathy, 2 valvular disease, 2 arrhythmogenic right ventricular cardiomyopathy, 1 giant cell myocarditis, 1 lymphocytic myocarditis).
I
Intervention
Detection of Enterovirus genome in native hearts using RT-PCR
C
Comparator
Patients without Enterovirus positivity in native hearts
O
Outcome
Post-transplantation outcomes including rejection and disease recurrence or deathhard clinical
Enterovirus infection in native hearts prior to transplantation may predict a poor prognosis, including severe rejection or disease recurrence.
Cite This Study
Valente et al. (1999) studied this question.