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Does interferon play a role in the initiation and maintenance of the carrier state in calf kidney cell cultures persistently infected with FMDV?
Does interferon play a role in the initiation and maintenance of the carrier state in calf kidney cell cultures persistently infected with FMDV?
Interon plays a major role in the initiation and maintenance of the carrier state in calf kidney cells persistently infected with foot-and-mouth disease virus.
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Interferon may sustain viral persistence in cell models; leaves open in vivo relevance or therapeutic targeting.
SUMMARY: Calf kidney cell cultures persistently infected with foot-and-mouth disease virus (FMDV) resist challenge with related and unrelated viruses. Attachment of challenge virus to persistently infected cells is not impaired. A challenge with viral ribonucleic acid (RNA) will not overcome the resistance of persistently infected cells. The initiation of persistence is correlated with the amount of interferon produced in the cells. It is concluded that interferon plays a major role in initiation and maintenance of the carrier state of the cells.
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Philipson et al. (1963) studied this question.
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