Population
Single ventricular cells from guinea pigs
Comparison
Caffeine (10 mM) vs Control conditions without caffeine
Design
Preclinical
Authors
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Caffeine may directly suppress cardiac INa; leaves open any role in human arrhythmia risk.
Caffeine directly inhibits Na+ current and shifts inactivation kinetics in guinea pig ventricular cells, independent of intracellular signaling systems.
Habuchi et al. (1991) studied this question.
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