Key result
Trypanosoma cruzi seropositivity was 45% in baboons with non-specific lymphocytic myocarditis versus 2-3% colony prevalence, and lesion severity was significantly higher in seropositive baboons.
Why the study?
Is Trypanosoma cruzi infection associated with non-specific lymphocytic myocarditis in baboons?
Case-Control (n=42)
Is Trypanosoma cruzi infection associated with non-specific lymphocytic myocarditis in baboons?
Trypanosoma cruzi infection is associated with non-specific lymphocytic myocarditis and increased lesion severity in baboons.
T. cruzi–myocarditis association in baboons supports primate models; leaves open human Chagas relevance.
Non-specific lymphocytic myocarditis (NLM) is frequently observed in baboons within the endemic range of Trypanosoma cruzi. We sought to determine whether T. cruzi infection is a cause of baboon NLM. We evaluated serial histologic sections of cardiac muscle, blood cultures, immunohistochemistry, serology, polymerase chain reaction, and clinical pathology from 31 baboons with NLM to determine whether T. cruzi infection is associated with NLM. Eleven baboons with no evidence of T. cruzi infection by serology and no NLM were used as controls. Seropositivity for T. cruzi was 45% in baboons with NLM compared with a 2-3% colony prevalence. NLM lesion severity was significantly higher in seropositive than seronegative baboons with NLM. NLM was significantly more common in older baboons. No statistical association between NLM and sex, weight, or clinical pathology was found. These results suggest an association between NLM and T. cruzi infection in the baboon.
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Andrade et al. (2009) conducted a case-control in Non-specific lymphocytic myocarditis (NLM) (n=42). Trypanosoma cruzi infection vs. No Trypanosoma cruzi infection was evaluated on Seropositivity for T. cruzi. Trypanosoma cruzi seropositivity was 45% in baboons with non-specific lymphocytic myocarditis versus 2-3% colony prevalence, and lesion severity was significantly higher in seropositive baboons.
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