Key result
Rhesus monkeys experimentally infected with T. cruzi for 15-19 years developed chronic chagasic cardiomyopathy, with abnormal electrocardiographic (3 of 6) and echocardiographic (1 of 6) patterns.
Why the study?
Does experimental infection with Trypanosoma cruzi in rhesus monkeys lead to chronic chagasic cardiomyopathy?
Population
Seven rhesus monkeys (Macaca mulatta) infected with the Colombian strain of Trypanosoma cruzi for 15-19 years.
Design
Preclinical
Follow-up
15-19 years
Authors
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Supports rhesus monkeys as a preclinical model for chronic chagasic cardiomyopathy; leaves open human translation pending further validation.
Does experimental infection with Trypanosoma cruzi in rhesus monkeys lead to chronic chagasic cardiomyopathy?
Rhesus monkeys experimentally infected with T. cruzi develop chronic chagasic cardiomyopathy, providing a viable preclinical model for the disease.
Carvalho et al. (2003) studied Chronic Chagas' disease (n=7). Trypanosoma cruzi infection (Colombian strain) was evaluated on Parasitemia, serology, electrocardiography, echocardiography, and radiology abnormalities. Rhesus monkeys experimentally infected with T. cruzi for 15-19 years developed chronic chagasic cardiomyopathy, with abnormal electrocardiographic (3 of 6) and echocardiographic (1 of 6) patterns.
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