Absence of left ventricular dysfunction during acute chagasic myocarditis in the rhesus monkey.
Why the study?
Does acute Trypanosoma cruzi infection impair left ventricular function in rhesus monkeys?
Population
Six rhesus monkeys
Comparison
Inoculation with Trypanosoma cruzi (7.5 X 10… vs Baseline (control) measurements prior to infection
Design
Preclinical
Follow-up
10 weeks
Authors
Discussion
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Member takes
Implication
Acute T. cruzi infection spares LV function until death in rhesus monkeys; hypothesis-generating for mechanisms of mortality in human Chagas disease.
Structured PICO
Does acute Trypanosoma cruzi infection impair left ventricular function in rhesus monkeys?
P
Population
Six rhesus monkeys
I
Intervention
Inoculation with Trypanosoma cruzi (7.5 X 10(3) parasites each) from a human patient with Chagas' disease into the subconjunctivae
C
Comparator
Baseline (control) measurements prior to infection
O
Outcome
Global left ventricular function (end-diastolic area and fractional change in area) and regional left ventricular function assessed by two-dimensional echocardiographysurrogate
Acute chagasic myocarditis in a rhesus monkey model does not cause significant left ventricular dysfunction despite severe parasitemia and mortality.
Cite This Study
Lima et al. (1986) studied this question.