What is the clinical evidence from this study?

Study design: Other. Population: Chagas' disease. Intervention: Trypanosoma cruzi infection. Primary outcome: Parasitological, immunological, hematological, and anatomo-pathological parameters.

June 1, 1990Memórias do Instituto Oswaldo CruzOpen Access

Experimental chagas' disease in rhesus monkeys. I. Clinical parasitological, hematological and anatomo-pathological studies in the acute and indeterminate phase of the disease

View Full Paper

Ask AI

Bookmark

Key result

T. cruzi infection in rhesus monkeys successfully reproduces features of acute and indeterminate human Chagas disease.

Population

Rhesus monkeys (Macaca mulatta)

Design

Preclinical

Follow-up

1 month to over 3 years

Authors

MBMaria da Glória Bonecini-AlmeidaInstituto Evandro Chagas BGBernardo Galvão‐CastroEscola Bahiana de Medicina e Saúde Pública MPMaria Heleosina Ribeiro Pessoa

Discussion

Member takes

Implication

Validates rhesus monkey model for acute/indeterminate Chagas phases; leaves open translation to human therapies.

Structured PICO

Population

Rhesus monkeys experimentally infected with Trypanosoma cruzi and followed for up to 3 years to evaluate disease progression.

Intervention

Subcutaneous infection with 1.0 x 10(4) to 1.5 x 10(4) metacyclic trypomastigotes of Trypanosoma cruzi (Colombian strain)

Outcome

Parasitological, immunological, hematological, electrocardiographic, and anatomo-pathological parameterssurrogate

Rhesus monkeys infected with T. cruzi serve as a viable experimental model for the acute and indeterminate phases of human Chagas' disease, including the development of myocarditis.

Cite This Study

Bonecini-Almeida et al. (1990) studied Chagas' disease. Trypanosoma cruzi infection was evaluated on Parasitological, immunological, hematological, and anatomo-pathological parameters. Experimental subcutaneous infection of rhesus monkeys with Trypanosoma cruzi successfully reproduced the clinical, parasitological, and pathological features of acute and indeterminate human Chagas' disease.

synapsesocial.com/papers/6aa36aead5ccfe0ebfb718b5 https://doi.org/10.1590/s0074-02761990000200004

View Full Paper

Ask AI

Bookmark

Experimental chagas' disease in rhesus monkeys. I. Clinical parasitological, hematological and anatomo-pathological studies in the acute and indeterminate phase of the disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Experimental chagas' disease in rhesus monkeys. I. Clinical parasitological, hematological and anatomo-pathological studies in the acute and indeterminate phase of the disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider