Key result
Trypanosoma cruzi tissue forms were detected in the myocardium of 84.6% of chronic chagasic patients by immunohistochemistry and 91.3% by PCR, demonstrating parasite persistence.
Cross-Sectional (n=28)
No
Trypanosoma cruzi parasites persist in the myocardium of chronic chagasic patients, suggesting their potential for causing heart damage is comparable to the acute phase and highlighting the need for new long-term antiparasitic drugs.
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Does not yet support routine antiparasitic therapy in chronic Chagas cardiomyopathy; leaves open the role of parasite eradication in preventing progression.
Añez et al. (1999) conducted a cross-sectional in Chronic Chagas' disease (n=28). Trypanosoma cruzi infection was evaluated on Detection of T. cruzi persistence in myocardium by PCR. Trypanosoma cruzi tissue forms were detected in the myocardium of 84.6% of chronic chagasic patients by immunohistochemistry and 91.3% by PCR, demonstrating parasite persistence.
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